姓名：王德坤

职称：副教授

一、教育经历：

2016/09-2019/06，永利官网，生物化学与分子生物学，博士

2008/09-2011/06，永利官网，遗传学，硕士

2004/09-2008/06，山东大学，生物技术，学士

二、工作经历：

2011/07-2016/08，永利官网，304am永利集团，实验师

2019/07-2023/12，永利官网，304am永利集团，讲师

2023/12至今，永利官网，304am永利集团，副教授

三、研究方向

肾脏病发病机制及治疗策略

四、承担课题项目

1、国家自然科学基金青年项目，Legumain通过维持溶酶体稳态抑制肾间质纤维化的机制研究，项目编号82000708，起止时间2021/01-2023/12（主持）

2、天津市自然科学基金青年项目，丹参酚酸B通过靶向AnnexinA2缓解糖尿病肾病肾损伤的作用及机制研究，项目编号21JCQNJC00160，起止时间2021/10-2023/09（主持）

3、国家自然科学基金面上项目，诱发肾结石形成的结晶过程分子机制及多尺度调控，项目编号2023B1-0037，起止时间2023/01-2026/12（合作）

五、发表论文：(第一/通讯)

1. Xuan Liu; Donghui Zhou; Yu Su; Hongling Liu; Qiuyue Su; Tianyu Shen; Mianzhi Zhang; Xue Mi; Yuying Zhang; Shijing Yue; Zhujun Zhang; Dekun Wang*; Xiaoyue Tan*; PDIA4 targets IRE1α/sXBP1 to alleviate NLRP3 inflammasome activation and renal tubular injury in diabetic kidney disease, BBA - Molecular Basis of Disease, 2025, 1871: 42-52 

2. Bo Dai; Xuan Liu; Mengwei Du; Shuangshuang Xie; Lin Dou; Xue Mi; Donghui Zhou; Yu Su; Tianyu Shen; Yuying Zhang; Shijing Yue; Dekun Wang*; Xiaoyue Tan*; LATS1 inhibitor and zinc supplement synergistically ameliorates contrast-induced acute kidney injury: Induction of Metallothionein-1 and suppression of tubular ferroptosis, Free Radical Biology and Medicine, 2024, 223: 42-52  

3. Zedong Zhang^#; Dekun Wang^#; Chang Liu; Jianguo Dong; Mengmeng Jiang; Xue Mi; Xiaoyue Tan; Yuying Zhang*; Penetration-then-growth enables label-free surface-enhanced Raman spectroscopic discrimination of fibrotic cells and kidney tissues, Sensors and Actuators: B. Chemical, 2023, 392(134103) 

4. Lichun Kang^#; Dekun Wang^#; Tianyu Shen; Xuan Liu; Bo Dai; Donghui Zhou; Huan Shen; Junbo Gong; Gang Li; Yuanjing Hu; Peng Wang; Xue Mi; Yuying Zhang; Xiaoyue Tan*; PDIA4 confers resistance to ferroptosis via induction of ATF4/SLC7A11 in renal cell carcinoma, Cell Death & Disease, 2023, 14(193) 

5. Bo Dai; Qiuyue Su; Xuan Liu; Xue Mi; Lin Dou; Donghui Zhou; Yu Su; Tianyu Shen; Yuying Zhang; Wenqing Xu; Xiaoyue Tan; Dekun Wang*; 2, 2-Dimethylthiazolidine hydrochloride protects against experimental contrast-induced acute kidney injury via inhibition of tubular ferroptosis, Biochemical and Biophysical Research Communications, 2023, S0006-291X(23)(00998-1)

6. Dekun Wang; Lichun Kang; Chuan'ai Chen; Jiasen Guo; Lingfang Du; Donghui Zhou; Gang Li; Yuying Zhang; Xue Mi; Mianzhi Zhang; Shuxia Liu; Xiaoyue Tan*; Loss of legumain induces premature senescence and mediates aging-related renal fibrosis, Aging Cell, 2022

7. Lingfang Du; Bo Dai; Xuan Liu; Donghui Zhou; Heng Yan; Tianyu Shen; Dekun Wang*; Xiaoyue Tan*; KDM6B regulates M2 polarization of macrophages by modulating the stability of nuclear β-catenin, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2022, 1869(2): 166611

8. Donghui Zhou; Yan Wu; Heng Yan; Tianyu Shen; Si Li; Junbo Gong; Gang Li; Haixing Mai; Dekun Wang*; Xiaoyue Tan*; Gallic acid ameliorates calcium oxalate crystal-induced renal injury via upregulation of Nrf2/HO-1 in the mouse model of stone formation, Phytomedicine, 2022, 106: 154429-154429

9. Shuyuan Wang; Zhen Yuan; Xiaoyue Tan*; Dekun Wang*; New Insights into the Mechanisms of Chaperon-Mediated Autophagy and Implications for Kidney Diseases, Cells, 2022, 11(406) 

10. Dekun Wang; Min Xiong; Chuan'ai Chen; Lingfang Du; Ze liu; Yuzhi Shi; Mianzhi Zhang; Junbo Gong; Xiangrong Song; Rong Xiang; Ergang Liu; Xiaoyue Tan*; Legumain, an asparaginyl endopeptidase, mediates the effect of M2 macrophages on attenuating renal interstitial fibrosis in obstructive nephropathy., Kidney International, 2018, 94(1): 91-101

11. Dekun Wang^#; Qingwen Meng^#; Lihong Huo; Meng Yang; Lingling Wang; Xinyu Chen; Jianchao Wang; Zhiguo Li; Xiaoying Ye; Na Liu; Qiuyan Li; Zhen Dai; Hongsheng Ouyang; Ning Li; Jun Zhou*; Lingyi Chen*; Lin Liu*; Overexpression of Hdac6 enhances resistance to virus infection in embryonic stem cells and in mice., Protein & Cell, 2015, 6(2): 152-156

六、讲授课程：

1、病理学

2、口腔组织病理学

3、临床医学概论

4、病理学技术

七、联系方式：

通讯地址：天津市南开区卫津路94号

E-mail：wangdekun@nankai.edu.cn